[CAS NO. 7029-89-2] DPBQ
PRODUCTS SPECIFICATIONS [7029-89-2]
DESCRIPTION [7029-89-2]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 362.38 |
| Molecular Formula | C24H14N2O2 |
| SMILES | O=C(C1=CC=CC=C12)C3=C(N=C(C4=CC=CC=C4)C(C5=CC=CC=C5)=N3)C2=O |
1 Publications Citing Use of MCE
Summary
DPBQ activates p53 and triggers apoptosis in a polyploid-specific manner, but does not inhibit topoisomerase or bind DNA. DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cells [1] .
IC50 & Target
p53 [1]
In Vitro
DPBQ elicits apoptosis and cell death and is selective for effects in 4N cells. DPBQ elicits expression and phosphorylation of p53 and this effect is specific to tetraploid cells. Knockdown of TP53 restores proliferation of tetraploid cells in the presence of DPBQ [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 2.94 mg/mL ( 8.11 mM ; ultrasonic and warming and heat to 80°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7595 mL | 13.7977 mL | 27.5953 mL |
| 5 mM | 0.5519 mL | 2.7595 mL | 5.5191 mL |
| 10 mM | --- | --- | --- |