[CAS NO. 71140-51-7] (R)-Mephenytoin

Name: (R)-Mephenytoin
Brand: Arctom Scientific
SKU: AS269710

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PRODUCTS SPECIFICATIONS [71140-51-7]

Distributor

Catalog

AS269710

Brand

Arctom Scientific

CAS

71140-51-7

DESCRIPTION [71140-51-7]

Overview

MDL	MFCD00272651
Molecular Weight	218.25
Molecular Formula	C12H14N2O2
SMILES	O=C1[C@@](C2=CC=CC=C2)(NC(N1C)=O)CC

For research use only. We do not sell to patients.

Summary

(R)-Mephenytoin ((-)-Mephenytoin), the R-enantiomer of Mephenytoin. Mephenytoin is an Anticonvulsant agent ^[1] ^[2] .

In Vitro

(R)-Mephenytoin can be N-demethylated by the cytochrome P450 (CYP) isoform CYP2C9 to form the metabolite 5-phenyl-5-ethylhydantoin (nirvanol) ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 220 mg/mL ( 1008.02 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.5819 mL	22.9095 mL	45.8190 mL
5 mM	0.9164 mL	4.5819 mL	9.1638 mL
10 mM	0.4582 mL	2.2910 mL	4.5819 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 5.5 mg/mL (25.20 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 5.5 mg/mL (25.20 mM); Clear solution

* All of the co-solvents are available by MCE.