[CAS NO. 714240-31-0] NCGC00029283
PRODUCTS SPECIFICATIONS [714240-31-0]
DESCRIPTION [714240-31-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 337.30 |
| Molecular Formula | C18H12FN3O3 |
| SMILES | O=C1NC2=C(C=C(OC)C=C2)C=C1C3=NOC(C4=CC=C(F)C=C4)=N3 |
Summary
NCGC00029283 is a werner syndrome helicase-nuclease (WRN) helicase inhibitor with IC 50 s of 2.3 μM, 12.5 μM, and 3.4 μM for WRN, BLM and FANCJ helicase, respectively [1] .
In Vitro
NCGC00029283 (0-100 μM; 24-72 h) effectively blocks cell proliferation in U2-OS cells [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay [1]
| Cell Line: | U2-OS cells |
| Concentration: | 1 μM, 10 μM, 100 μM |
| Incubation Time: | 24 h, 48 h, 72 h |
| Result: | Showed a reduction in U2-OS cell proliferation. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 6.94 mg/mL ( 20.58 mM ; ultrasonic and warming and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.9647 mL | 14.8236 mL | 29.6472 mL |
| 5 mM | 0.5929 mL | 2.9647 mL | 5.9294 mL |
| 10 mM | 0.2965 mL | 1.4824 mL | 2.9647 mL |
