[CAS NO. 72203-93-1] Calcitetrol
PRODUCTS SPECIFICATIONS [72203-93-1]
DESCRIPTION [72203-93-1]
Overview
| MDL | MFCD22124496 |
|---|---|
| Molecular Weight | 432.64 |
| Molecular Formula | C27H44O4 |
| SMILES | O[C@@H](C[C@H](O)C/1=C)CC1=C\C=C2[C@@](CC[C@@H]3[C@@H](CCC(O)C(C)(O)C)C)([H])[C@]3(C)CCC\2 |
Summary
Calcitetrol(1α, 24, 25-Trihydroxy VD3) is the hormonally active form of vitamin D with three hydroxyl groups. IC50 value: Target: Calcitriol increases blood calcium levels ([Ca2+]) by promoting absorption of dietary calcium from the gastrointestinal tract and increasing renal tubular reabsorption of calcium, thus reducing the loss of calcium in the urine. Calcitriol also stimulates release of calcium from bone by its action on the specific type of bone cells referred to as osteoblasts, causing them to release RANKL , which in turn activates osteoclasts.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Solvent & Solubility
DMSO : 100 mg/mL ( 231.14 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3114 mL | 11.5570 mL | 23.1139 mL |
| 5 mM | 0.4623 mL | 2.3114 mL | 4.6228 mL |
| 10 mM | 0.2311 mL | 1.1557 mL | 2.3114 mL |
References
- [1] Johanna A. Huhtakangas, Christopher J. Olivera, June E. Bishop et al. The Vitamin D Receptor Is Present in Caveolae-Enriched Plasma Membranes and Binds 1α,25(OH)2-Vitamin D3in Vivo and in Vitro. Molecular Endocrinology November 1, 2004 vol. 18 no. 11 2660
- [2] Robert A. Parise, Merrill J. Egorin, Beatriz Kanterewicz et al. CYP24, the enzyme that catabolizes the antiproliferative agent vitamin D, is increased in lung cancer. International Journal of Cancer. Volume 119, Issue 8, pages 1819-1828, 15 October 2006
- [3] Akiyoshi-Shibata M, Sakaki T, Ohyama Y, Noshiro M, Okuda K, Yabusaki Y. Further oxidation of hydroxycalcidiol by calcidiol 24-hydroxylase. A study with the mature enzyme expressed in Escherichia coli. Eur J Biochem. 1994 Sep 1;224(2):335-43.
- [4] Sonoko Masuda, Valarie Byford, Alice Arabian et al. Altered Pharmacokinetics of 1α,25-Dihydroxyvitamin D3 and 25-Hydroxyvitamin D3 in the Blood and Tissues of the 25-Hydroxyvitamin D-24-Hydroxylase (Cyp24a1) Null Mouse. Endocrinology February 1, 2005 vol.
