[CAS NO. 726174-00-1] A-381393
PRODUCTS SPECIFICATIONS [726174-00-1]
DESCRIPTION [726174-00-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 320.43 |
| Molecular Formula | C20H24N4 |
| SMILES | CC1=CC=C(C=C1C)N2CCN(CC2)CC3=NC4=CC=CC=C4N3 |
Summary
A-381393 is a potent, selective, brain penetrate dopamine D 4 receptor antagonist, with K i s of 1.5, 1.9 and 1.6 nM for human dopamine D 4.4 , D 4.2 , and D 4.7 receptor, respectively, >2700-fold selectivity over D 1 , D 2 , D 3 and D 5 dopamine receptors. A-381393 shows moderate affinity for 5-HT 2A (K i , 370 nM) [1] .
IC50 & Target
Ki: 1.5 nM (D 4.4 receptor), 1.9 nM (D 4.2 receptor), 1.6 nM (D 4.7 receptor) [1]
In Vitro
A-381393 exhibits weak affinity at 5-HT 1A , Sigma 2, Adenoceptor α 1A , Adenoceptor α 2C , Histamine H1, with K i s of 1365, 8600, 2044, 1912 and 2962 nM, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 51.67 mg/mL ( 161.25 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.1208 mL | 15.6040 mL | 31.2081 mL |
| 5 mM | 0.6242 mL | 3.1208 mL | 6.2416 mL |
| 10 mM | 0.3121 mL | 1.5604 mL | 3.1208 mL |
