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[CAS NO. 7424-00-2] Fenclonine
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-B1368 |
| Brand: | MCE |
| CAS: | 7424-00-2 |
Overview
| MDL | - |
|---|---|
| Molecular Weight | 199.63 |
| Molecular Formula | C9H10ClNO2 |
| SMILES | NC(CC1=CC=C(Cl)C=C1)C(O)=O |
10 Publications Citing Use of MCE
- [1]Food Chem. 2022 Dec 9;407:135172.
- [2]Food Chem. 2021 Mar 1;339:127864.
- [3]Food Res Int. 1 November 2022, 112088.
- [4]J Agric Food Chem. 2022 Nov 28.
- [5]J Agric Food Chem. 2022 May 11;70(18):5701-5714.
- [6]J Agric Food Chem. 2019 Oct 30;67(43):12084-12093.
- [7]J Agric Food Chem. 2019 May 15;67(19):5423-5436.
- [8]Lwt-Food Sci Technol. 21 July 2022, 113791.
- [9]LWT-FOOD SCI TECHNOL. 2021, 110963.
- [10]J Pharm Pharmacol. 2020 Sep;72(9):1256-1268.
Summary
Fenclonine is a selective and irreversible tryptophan hydroxylase inhibitor, which is a rate-limiting enzyme in the biosynthesis of serotonin. Fenclonine can be used in carcinoid syndrome research [1] [2] [3] .
In Vivo
Fenclonine (intraperitoneal injection; 100 mg/kg; once daily; 3 d) treatment can inhibit Morphine-induced anti-nociceptive activity
[2]
.
Fenclonine (intraperitoneal injection; 300 mg/kg; once daily; 3 d) pretreatment completely abolishes the effects of a 50 mg/kg dose of Paracetamol
[3]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Wistar albino rats of either sex and weighing between 80 and 100 g [2] |
| Dosage: | 100 mg/kg |
| Administration: | Intraperitoneal injection; 100 mg/kg; once daily; 3 days |
| Result: | Inhibited the antinociceptive activity of Morphine by 41.5%. |
| Animal Model: | Male Swiss mice (22–25 g) [3] |
| Dosage: | 300 mg/kg |
| Administration: | Intraperitoneal injection; 300 mg/kg; once daily; 3 days |
| Result: | Inhibited the effects of Paracetamol in depression-like and compulsion-like behavior. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 500.93 mM ; ultrasonic and adjust pH to 2 with HCl)
H 2 O : 4.55 mg/mL ( 22.79 mM ; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.0093 mL | 25.0463 mL | 50.0927 mL |
| 5 mM | 1.0019 mL | 5.0093 mL | 10.0185 mL |
| 10 mM | 0.5009 mL | 2.5046 mL | 5.0093 mL |
-
1.
Add each solvent one by one: 0.5% CMC-Na /saline water
Solubility: 20 mg/mL (100.19 mM); Suspended solution; Need ultrasonic
-
2.
-
3.
Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (12.52 mM); Clear solution
-
4.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (12.52 mM); Clear solution
References
- [1] M Jouvet. Sleep and serotonin: an unfinished story. Neuropsychopharmacology. 1999 Aug;21(2 Suppl):24S-27S.
- [2] A K Sanyal, et al. Prostaglandins: antinociceptive effect of prostaglandin E1 in the rat. Clin Exp Pharmacol Physiol. 1977 May-Jun;4(3):247-55.
- [3] Shyamshree S S Manna, et al. Paracetamol potentiates the antidepressant-like and anticompulsive-like effects of fluoxetine. Behav Pharmacol. 2015 Apr;26(3):268-81.
Synonyms
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