[CAS NO. 7460-82-4] Diethylene glycol bis(p-toluenesulfonate)

Name: Diethylene glycol bis(p-toluenesulfonate)
Brand: Arctom Scientific
SKU: AS104590

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PRODUCTS SPECIFICATIONS [7460-82-4]

Distributor

Catalog

AS104590

Brand

Arctom Scientific

CAS

7460-82-4

DESCRIPTION [7460-82-4]

Overview

MDL	MFCD00026001
Molecular Weight	414.49
Molecular Formula	C18H22O7S2
SMILES	O=S(C1=CC=C(C)C=C1)(OCCOCCOS(C2=CC=C(C)C=C2)(=O)=O)=O

For research use only. We do not sell to patients.

Summary

Diethylene glycol bis(p-toluenesulfonate) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs ^[1] .

IC50 & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

References

[1] Snaebjornsson MT, et al. Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways. Exp Mol Med. 2018 Apr 16;50(4):34.

Synonyms

Ethanol, 2,2′-oxybis-, 1,1′-bis(4-methylbenzenesulfonate)

Ethanol, 2,2′-oxybis-, bis(4-methylbenzenesulfonate)

Diethylene glycol di-p-toluenesulfonate

Diethylene glycol ditosylate

Bis[β-(4-toluenesulfonyloxy)ethyl] ether

2,2′-Oxybis(ethyl tosylate)

3-Oxapentane-1,5-diol ditosylate

Bis(2-tosyloxyethyl) ether

Diethylene glycol bis(4-toluenesulfonate)

3-Oxa-1,5-pentanediyl bis(p-toluenesulfonate)

1,5-Bis(p-tolylsulfonyloxy)-3-oxapentane

1,5-Bis(tosyloxy)-3-oxapentane

Diethylene glycol di-p-tosylate

Diethylene glycol bis(p-toluenesulfonate)

Diethylene glycol bis(p-tosylate)

2,2′-Oxybisethanol bis(4-methylbenzenesulfonate)

Di(2-tosyloxyethyl) ether

NSC 404215

2-[2-(4-Methylphenyl)sulfonyloxyethoxy]ethyl 4-methylphenylsulfonate

2-[2-(4-Methylphenyl)sulfonyloxyethoxy]ethyl 4-methylbenzenesulfonate