[CAS NO. 74764-40-2] Bepridilhydrochloridehydrate

Name: Bepridilhydrochloridehydrate
Brand: Arctom Scientific
SKU: AS197944

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PRODUCTS SPECIFICATIONS [74764-40-2]

Distributor

Catalog

AS197944

Brand

Arctom Scientific

CAS

74764-40-2

DESCRIPTION [74764-40-2]

Overview

MDL	MFCD00065498
Molecular Weight	421.02
Molecular Formula	C24H37ClN2O2
SMILES	CC(C)COCC(N1CCCC1)CN(C2=CC=CC=C2)CC3=CC=CC=C3.[H]Cl.[H]O[H]

For research use only. We do not sell to patients.

2 Publications Citing Use of MCE

Summary

Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) is a non-selective, long-acting Ca ⁺ channel antagonist and Na ⁺ , K ⁺ channel inhibitor, with antianginal and type I antiarrhythmic effects. Bepridil hydrochloride hydrate also acts as a cardiac Na ⁺ /Ca2 ⁺ exchange (NCX1) inhibitor. Bepridil hydrochloride hydrate can be used for the research of cardiovascular disorders ^[1] ^[2] ^[3] ^[4] ^[5] .

In Vitro

Bepridil hydrochloride hydrate blockades of Ca ²⁺ -dependent action potentials in vascular smooth muscle of dog coronary artery ^[2] .
Bepridil hydrochloride hydrate blocks Ca currents and Na currents with IC ₅₀ s of 0.5 μM and 30 μM, respectively in cultured ventricular cells ^[4] .
Bepridil hydrochloride hydrate decreases I _Ks under blockade of I _Kr with E4031 (5 μM), in a concentration-dependent manner ^[5] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Bepridil hydrochloride hydrate exhibits a half-life of averages 33±15 hours after single-dose administration ^[6] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 296.90 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3752 mL	11.8759 mL	23.7518 mL
5 mM	0.4750 mL	2.3752 mL	4.7504 mL
10 mM	0.2375 mL	1.1876 mL	2.3752 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (4.94 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (4.94 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (4.94 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

1-Pyrrolidineethanamine, β-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-, hydrochloride, hydrate (1:1:1)

1-Pyrrolidineethanamine, β-[(2-methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-, monohydrochloride, monohydrate