[CAS NO. 749269-83-8] Itanapraced (CHF 5074)
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PRODUCTS SPECIFICATIONS [749269-83-8]
Distributor
Catalog
AS942143
Brand
Arctom Scientific
CAS
749269-83-8
DESCRIPTION [749269-83-8]
Overview
| MDL | MFCD18633206 |
|---|---|
| Molecular Weight | 325.16 |
| Molecular Formula | C16H11Cl2FO2 |
| SMILES | O=C(C1(C2=CC=C(C3=CC=C(Cl)C(Cl)=C3)C(F)=C2)CC1)O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0754 mL | 15.3770 mL | 30.7541 mL |
| 5 mM | 0.6151 mL | 3.0754 mL | 6.1508 mL |
| 10 mM | 0.3075 mL | 1.5377 mL | 3.0754 mL |
| 50 mM | 0.0615 mL | 0.3075 mL | 0.6151 mL |
Description
Itanapraced (CHF 5074, CSP-1103) is a modulator that reduces Aβ42 and Aβ40 secretion. The IC50s of CHF5074 for inhibition of COX-1 and COX-2 is above 100 μmol/L.
Targets
| Secretase [1] |
In vitro
In human neuroglioma cells over-expressing the Swedish mutated APP [human neuroglioma cell line expressing APPswe (H4swe)], CHF5074 preferentially lowers Aβ42 secretion with an IC50 of 3.6 µmol/L. CHF5074 does not display inhibitory activity on COX-1 and COX-2 enzymes when employed at concentrations up to 100 µmol/L and 300 µmol/L respectively.
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