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[CAS NO. 77307-50-7] SL0101-1
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-15237 |
| Brand: | MCE |
| CAS: | 77307-50-7 |
Overview
| MDL | MFCD09842349 |
|---|---|
| Molecular Weight | 516.45 |
| Molecular Formula | C25H24O12 |
| SMILES | OC1=CC(O)=C(C(C(O[C@@H]2O[C@@H](C)[C@H](OC(C)=O)[C@@H](OC(C)=O)[C@H]2O)=C(C3=CC=C(O)C=C3)O4)=O)C4=C1 |
3 Publications Citing Use of MCE
Summary
SL 0101-1 (SL0101), a kaempferol glycoside, isolated from the tropical plant F. refracta , is a cell-permeable, selective, reversible, ATP-competitive p90 Ribosomal S6 Kinase (RSK) inhibitor, with an IC 50 of 89 nM [1] . SL 0101-1 (SL0101) is a selective RSK1/2 inhibitor, with a K i of 1 μM [2] .
IC50 & Target
|
RSK1
|
In Vitro
SL 0101-1 (SL0101) shows proliferation inhibition in human breast cancer cell line MCF-7 and produces a cell cycle block in G 1 phase [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
References
- [1] Smith JA, et al. Identification of the first specific inhibitor of p90 ribosomal S6 kinase (RSK) reveals an unexpected role for RSK in cancer cell proliferation. Cancer Res. 2005 Feb 1;65(3):1027-34.
- [2] Yu Li, et al. The Affinity of RSK for Cylitol Analogues of SL0101 Is Critically Dependent on the B-ring C-4'-hydroxy. Chem Commun (Camb). 2020 Mar 10;56(20):3058-3060.
Synonyms
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