[CAS NO. 77544-68-4] Tos-PEG3
PRODUCTS SPECIFICATIONS [77544-68-4]
DESCRIPTION [77544-68-4]
Overview
| MDL | MFCD18433414 |
|---|---|
| Molecular Weight | 304.36 |
| Molecular Formula | C13H20O6S |
| SMILES | OCCOCCOCCOS(C1=CC=C(C)C=C1)(=O)=O |
Summary
Tos-PEG3 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs . Tos-PEG3 (structure 1) can be used for the synthesis of 3'-aminooxy oligonucleotides solid supports [1] .
In Vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid-liquid mixture
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
Ethanol : 100 mg/mL ( 328.56 mM ; Need ultrasonic)
DMSO : 100 mg/mL ( 328.56 mM ; Need ultrasonic and warming)
H 2 O : 10 mg/mL ( 32.86 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.2856 mL | 16.4279 mL | 32.8558 mL |
| 5 mM | 0.6571 mL | 3.2856 mL | 6.5712 mL |
| 10 mM | 0.3286 mL | 1.6428 mL | 3.2856 mL |
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1.
Add each solvent one by one: PBS
Solubility: 16.67 mg/mL (54.77 mM); Clear solution; Need ultrasonic
