[CAS NO. 779353-02-5]  CDK-IN-6

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PRODUCTS SPECIFICATIONS [779353-02-5]

Distributor
Catalog
AS383329
Brand
Arctom Scientific
CAS
779353-02-5

DESCRIPTION [779353-02-5]

Overview

MDL-
Molecular Weight380.49
Molecular FormulaC21H28N6O
SMILESCCC1=C2N(N=C1)C(NCC3=CN=CC=C3)=CC(N(CCCC4)[C@@H]4CCO)=N2

For research use only. We do not sell to patients.

Summary

CDK-IN-6, a class of pyrazolo[1,5-a]pyrimidine compound, is a CDK inhibitor with anticancer activities [1] .


In Vitro

Individual CDK's, such as, CDK1, CDK2, CDK3, CDK4, CDK5, CDK6 and CDK7, CDK8 and the like, perform distinct roles in cell cycle progression and can be classified as either G1, S, or G2M phase enzymes. Uncontrolled proliferation is a hallmark of cancer cells, and misregulation of CDK function occurs with high frequency in many important solid tumors [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Oil


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL ( 131.41 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6282 mL 13.1409 mL 26.2819 mL
5 mM 0.5256 mL 2.6282 mL 5.2564 mL
10 mM 0.2628 mL 1.3141 mL 2.6282 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (6.57 mM); Clear solution

* All of the co-solvents are available by MCE.