[CAS NO. 79455-30-4] Nicaraven

Name: Nicaraven
Brand: Arctom Scientific
SKU: AS509753

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PRODUCTS SPECIFICATIONS [79455-30-4]

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Catalog

AS509753

Brand

Arctom Scientific

CAS

79455-30-4

DESCRIPTION [79455-30-4]

Overview

MDL	MFCD00411904
Molecular Weight	284.31
Molecular Formula	C15H16N4O2
SMILES	C(NCC(NC(=O)C=1C=CC=NC1)C)(=O)C=2C=CC=NC2

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

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Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	3.5173 mL	17.5864 mL	35.1729 mL
5 mM	0.7035 mL	3.5173 mL	7.0346 mL
10 mM	0.3517 mL	1.7586 mL	3.5173 mL
50 mM	0.0703 mL	0.3517 mL	0.7035 mL

Description

Nicaraven is a hydroxyl radical scavenger with antivasospastic and neuroprotective effects.

In vitro

Nicaraven causes a dose-dependent, slight inhibition of poly (ADP-ribose) synthetase activation, possibly due to a direct inhibitory effect on the catalytic activity of poly (ADP-ribose) synthetase in RAW murine macrophages stimulated with peroxynitrite. Nicaraven partially protects against the peroxynitrite-induced suppression of mitochondrial respiration in RAW macrophages and causes a slight, dose-dependent inhibition of nitrite production in RAW macrophages stimulated with bacterial lipopolysaccharide. Nicaraven (0.35 mM) significantly inhibits the maximum aggregation rate induced by adenosine diphosphate (ADP) in the healthy volunteer platelets. Nicaraven (1.75 mM) significantly reduces the maximum aggregation rate induced by collagen in platelets. Nicaraven induces dose-dependent inhibition of platelet aggregation in both healthy volunteers and patients with cerebral thrombosis.

In vivo

Nicaraven inhibits lipid peroxidation in the liver of beagle dogs, improves hepatic and systemic hemodynamics and energy metabolism, and suppresses liver enzyme release, endothelin-1 elevation in hepatic venous blood, histologic damage, and neutrophil infiltration into the liver. Nicaraven (20 mg/kg) elicits small reductions in infarction volume in male Sprague-Dawley rats subjected to transient focal ischemia. Nicaraven (60 mg/kg) provides significant reductions in the volume of infarction (18.6% and 20.9%) reductions for the pre- and posttreatment groups, respectively, in male Sprague-Dawley rats subjected to transient focal ischemia.

References

[1] Zingarelli B, et al. Shock, 2000, 13(2), 126-134.
[2] Komiya T, et al. Clin Neuropharmacol, 1999, 22(1), 11-14.
[3] Yokota R, et al. Surgery, 2000, 127(6), 661-669.
[4] Toyoda T, et al. Neurosurgery, 1997, 40(2), 372-377.

Synonyms

3-Pyridinecarboxamide, N,N′-(1-methyl-1,2-ethanediyl)bis-

N,N′-(1-Methyl-1,2-ethanediyl)bis[3-pyridinecarboxamide]

AVS

Nicaraven

1,2-Bis(nicotinamido)propane

Antevas