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[CAS NO. 80433-71-2] LevoleucovorinCalcium
| Ships within | Stock | Price | Qty | Total |
Please click "REQUEST A QUOTE" button if there is no stock, or you need other sizes or custom synthesis.
| Catalog: | HY-13667 |
| Brand: | MCE |
| CAS: | 80433-71-2 |
Overview
| MDL | MFCD08704249 |
|---|---|
| Molecular Weight | 511.50 |
| Molecular Formula | C20H21CaN7O7 |
| SMILES | O=C1C2=C(NC[C@H](CNC3=CC=C(C(N[C@H](C([O-])=O)CCC([O-])=O)=O)C=C3)N2C=O)NC(N)=N1.[Ca+2] |
1 Publications Citing Use of MCE
Summary
Levoleucovorin Calcium (Calcium levofolinate), a levo isoform of Leucovorin Calcium (HY-13664), possesses antineoplastic effects. Levoleucovorin Calcium is also an augmentor of 5-fluorouracil (HY-90006) cytotoxicity against cancer [1] [2] .
In Vivo
Levoleucovorin Calcium (6, 20 or 60 mg/kg/day; i.v.; for 4 weeks) enhances the toxicity of 5-Fluorouracil [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Crj:CD(SD)BR rats (5 weeks) [2] |
| Dosage: | 6, 20 or 60 mg/kg/day |
| Administration: | i.v.; for 4 weeks (combined with 10 mg/kg/day 5-Fluorouracil ) |
| Result: |
Decreased the RBC counts, increased extramedullary hematopoiesis and enhanced the suppression of lymphatic organs.
Induced the potentiation in the toxicity of 5-Fluorouracil appeared to be mainly immuno-suppression and myelosuppression, which were related to the anti-tumor activity of 5-Fluorouracil. |
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date | Phase |
|---|---|---|---|---|
| NCT04949256 | Merck Sharp & Dohme LLC|Eisai Inc. |
Metastatic Esophageal Squamous Cell Carcinoma
|
July 28, 2021 | Phase 3 |
| NCT04210115 | Merck Sharp & Dohme LLC |
Esophageal Squamous Cell Carcinoma (ESCC)|Gastroesophageal Junction Carcinoma (GEJC)|Esophageal Adenocarcinoma (EAC)
|
February 28, 2020 | Phase 3 |
| NCT01882868 | Sanofi|Regeneron Pharmaceuticals |
Colorectal Cancer Metastatic
|
July 2013 | Phase 2 |
| NCT03698461 | Asan Medical Center|Hoffmann-La Roche |
Colorectal Neoplasms|Neoplasm Metastasis|Colonic Neoplasms|Rectal Neoplasms
|
May 15, 2019 | Phase 2 |
| NCT02497157 | Translational Research Center for Medical Innovation, Kobe, Hyogo, Japan|Hiroshima Prefectural Hospital|National Hospital Organization Shikoku Cancer Center |
Metastatic Colorectal Cancer
|
May 21, 2015 | Phase 2 |
| NCT04060017 | Rossignol Medical Center|State University of New York - Downstate Medical Center|United States Department of Defense|Southwest Autism Research & Resource Center |
Autism Spectrum Disorder|Language Disorders
|
September 22, 2020 | Phase 2 |
| NCT04745988 | National Cancer Center Hospital East|Merck Sharp & Dohme LLC |
Gastric Cancer
|
November 11, 2021 | Phase 2 |
| NCT05253651 | Seagen Inc.|Merck Sharp & Dohme LLC |
Colorectal Neoplasms
|
November 30, 2022 | Phase 3 |
| NCT04456699 | Merck Sharp & Dohme LLC |
Metastatic Colorectal Cancer
|
August 19, 2020 | Phase 3 |
| NCT03387592 | Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori |
Neuroendocrine Carcinoma
|
March 6, 2017 | Phase 2 |
| NCT03045770 | Fujian Cancer Hospital |
Advanced Gastric Cancer Adenocarcinoma of Esophagogastric Junction
|
February 10, 2017 | Not Applicable |
| NCT03222089 | Fujian Cancer Hospital |
Metastatic Colorectal Cancer
|
July 20, 2017 | Phase 2 |
| NCT05546853 | University Hospital, Grenoble|NETRIS Pharma |
Pancreatic Ductal Adenocarcinoma
|
November 2022 | Phase 1 |
| NCT02697058 | Institut de Recherches Internationales Servier|ADIR, a Servier Group company|Servier |
Metastatic Pancreatic Cancer
|
March 30, 2016 | Phase 2 |
| NCT04776655 | Azienda Unità Sanitaria Locale Reggio Emilia|Istituto Di Ricerche Farmacologiche Mario Negri|Istituto Nazionale Tumori IRCCS - Fondazione G. Pascale |
Colorectal Cancer|Metastatic Colorectal Cancer|RAS Mutation
|
April 30, 2021 | Phase 3 |
| NCT01286818 | Eli Lilly and Company |
Colorectal Carcinoma
|
February 2011 | Phase 1 |
| NCT04060030 | Rossignol Medical Center|Autism Speaks|State University of New York - Downstate Medical Center|Southwest Autism Research & Resource Center |
Autism Spectrum Disorder|Language Disorders
|
October 8, 2020 | Phase 2 |
| NCT02641873 | Sumitomo Pharma Co., Ltd. |
Metastatic Colorectal Cancer
|
December 2015 | Phase 1 |
| NCT01681472 | Isofol Medical AB |
Colonic Neoplasms
|
September 2012 | Phase 1|Phase 2 |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
H 2 O : 10 mg/mL ( 19.55 mM ; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9550 mL | 9.7752 mL | 19.5503 mL |
| 5 mM | 0.3910 mL | 1.9550 mL | 3.9101 mL |
| 10 mM | 0.1955 mL | 0.9775 mL | 1.9550 mL |
References
Synonyms
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