[CAS NO. 835616-60-9] Thalidomide4-fluoride

Name: Thalidomide4-fluoride
Brand: Arctom Scientific
SKU: AS907396

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PRODUCTS SPECIFICATIONS [835616-60-9]

Distributor

Catalog

AS907396

Brand

Arctom Scientific

CAS

835616-60-9

DESCRIPTION [835616-60-9]

Overview

MDL	MFCD11840666
Molecular Weight	276.22
Molecular Formula	C13H9FN2O4
SMILES	O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3F)=O

For research use only. We do not sell to patients.

Summary

Thalidomide 4-fluoride (Cereblon ligand 4) is the Thalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Thalidomide 4-fluoride (Cereblon ligand 4) can be connected to the ligand for IRAK4 protein by a linker to form PROTAC IRAK4 degrader-1 (HY-129966) ^[1] .

IC50 & Target

Cereblon

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 300 mg/mL ( 1086.09 mM ; Need ultrasonic)

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Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6203 mL	18.1015 mL	36.2030 mL
5 mM	0.7241 mL	3.6203 mL	7.2406 mL
10 mM	0.3620 mL	1.8102 mL	3.6203 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.