[CAS NO. 83805-11-2] Falecalcitriol
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PRODUCTS SPECIFICATIONS [83805-11-2]
Distributor
Catalog
AS280314
Brand
Arctom Scientific
CAS
83805-11-2
DESCRIPTION [83805-11-2]
Overview
| MDL | MFCD00870595 |
|---|---|
| Molecular Weight | 524.58 |
| Molecular Formula | C27H38F6O3 |
| SMILES | C[C@]([C@]/12[H])([C@H](CC2)[C@@H](CCCC(C(F)(F)F)(C(F)(F)F)O)C)CCCC1=C/C=C(C[C@@H](O)C[C@@H]3O)\C3=C |
For research use only. We do not sell to patients.
Summary
Falecalcitriol(Fulstan; Hornel) is an analog of calcitriol; has a higher potency both in vivo and in vitro systems, and longer duration of action in vivo.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light, stored under nitrogen
* The compound is unstable in solutions, freshly prepared is recommended.
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL ( 190.63 mM ; Need ultrasonic)
Preparing
Stock Solutions
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 1.9063 mL | 9.5314 mL | 19.0629 mL |
| 5 mM | 0.3813 mL | 1.9063 mL | 3.8126 mL |
| 10 mM | 0.1906 mL | 0.9531 mL | 1.9063 mL |
*
Please refer to the solubility information to select the appropriate solvent.
References
- [1] Ito H, Ogata H, Yamamoto M, Takahashi K, Shishido K, Takahashi J, Taguchi S, Kinugasa E. Comparison of oral falecalcitriol and intravenous calcitriol in hemodialysis patients with secondary hyperparathyroidism: a randomized, crossover trial. Clin Nephro
- [2] Tokunaga M, Tamura M, Kabashima N, Serino R, Shibata T, Matsumoto M, Miyamoto T, Miyazaki M, Furuno Y, Takeuchi M, Abe H, Okazaki M, Otsuji Y. Falecalcitriol for conventional vitamin D therapy-resistant secondary hyperparathyroidism in a continuous ambul
- [3] Iwao Y, Yamaguchi Y, Fujii K, Toba Y, Asada M, Nagano N, Yamamoto H, Hyoma K, Yamada S, Hirano H, Tone Y, Ohtani H, Saika Y, Fujii R. Long-term suppressive effect of falecalcitriol on parathyroid hormone secretion in secondary hyperparathyroidism in hemo
- [4] Morii H. Falecalcitriol as a new therapeutic agent for secondary hyperparathyroidismClin Calcium. 2005 Jan;15(1):29-33.
- [5] Ohtsuka N, Urayama K. Pharmacological action and clinical effects of falecalcitriol, a highly potent derivative of active vitamin D3.Nihon Yakurigaku Zasshi. 2002 Dec;120(6):427-36.
- [6] Jean-Pierre Bégué, Danièle Bonnet-Delpon.Recent advances (1995-2005) in fluorinated pharmaceuticals based on natural products. Journal of Fluorine Chemistry.Volume 127, Issue 8, August 2006, Pages 992-1012
Synonyms
1,3-Cyclohexanediol, 4-methylene-5-[(2E)-2-[1-[(1R)-6,6,6-trifluoro-5-hydroxy-1-methyl-5-(trifluoromethyl)hexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-, (1R,4S,5Z)-
9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol, 26,26,26,27,27,27-hexafluoro-, (1α,3β,5Z,7E)-
(1R,4S,5Z)-4-Methylene-5-[(2E)-2-[1-[(1R)-6,6,6-trifluoro-5-hydroxy-1-methyl-5-(trifluoromethyl)hexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol
26,26,26,27,27,27-Hexafluoro-1,25-dihydroxyvitamin D3
Ro 23-4194
(+)-(5Z,7E)-26,26,26,27,27,27-Hexafluoro-9,10-secocholesta-5,7,10(19)-triene-1α,3β,25-triol
ST 630
Falecalcitriol
Flocalcitriol
Fulstan
Hornel
Flocalcitrol
Flocacitriol
F6-1α,25-Dihydroxyvitamin D3
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