[CAS NO. 876345-13-0] Boc-NH-PEG4-CH2COOH
PRODUCTS SPECIFICATIONS [876345-13-0]
DESCRIPTION [876345-13-0]
Overview
| MDL | MFCD30528568 |
|---|---|
| Molecular Weight | 351.39 |
| Molecular Formula | C15H29NO8 |
| SMILES | O=C(O)COCCOCCOCCOCCNC(OC(C)(C)C)=O |
Summary
Boc-NH-PEG4-CH2COOH is a cleavable ADC linker used as a linker for antibody-drug conjugates (ADC). Boc-NH-PEG4-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1] .
IC50 & Target
|
Cleavable |
Alkyl/ether |
PEGs |
In Vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Viscous liquid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
References
