[CAS NO. 90729-42-3] Carebastine

Name: Carebastine
Brand: Arctom Scientific
SKU: AS488761

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [90729-42-3]

Distributor

Catalog

AS488761

Brand

Arctom Scientific

CAS

90729-42-3

DESCRIPTION [90729-42-3]

Overview

MDL	MFCD00865665
Molecular Weight	499.64
Molecular Formula	C32H37NO4
SMILES	O=C(CCCN1CCC(OC(C2=CC=CC=C2)C3=CC=CC=C3)CC1)C4=CC=C(C=C4)C(C)(C(O)=O)C

For research use only. We do not sell to patients.

Summary

Carebastine is the active metabolite of Ebastine. Carebastine is a histamine H1 receptor antagonist. Carebastine inhibits VEGF-induced HUVEC and HPAEC proliferation, migration and angiogenesis in a dose-dependent manner ^[1] . Carebastine suppresses the expression of macrophage migration inhibitory factor ^[2] .

IC50 & Target

H ₁ Receptor

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMF : 25 mg/mL ( 50.04 mM ; Need ultrasonic and warming)

DMSO : 2 mg/mL ( 4.00 mM ; Need ultrasonic and warming)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0014 mL	10.0072 mL	20.0144 mL
5 mM	0.4003 mL	2.0014 mL	4.0029 mL
10 mM	0.2001 mL	1.0007 mL	2.0014 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 2.5 mg/mL (5.00 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: 2.5 mg/mL (5.00 mM); Suspended solution; Need ultrasonic
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (5.00 mM); Clear solution

* All of the co-solvents are available by MCE.

References

Synonyms

Benzeneacetic acid, 4-[4-[4-(diphenylmethoxy)-1-piperidinyl]-1-oxobutyl]-α,α-dimethyl-

4-[4-[4-(Diphenylmethoxy)-1-piperidinyl]-1-oxobutyl]-α,α-dimethylbenzeneacetic acid

Carebastine

2-(4-(4-(4-(Benzhydryloxy)piperidin-1-yl)-butanoyl)phenyl)-2-methylpropanoic acid