[CAS NO. 924296-19-5] DUB-IN-2

Name: DUB-IN-2
Brand: Arctom Scientific
SKU: HY-50737A

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PRODUCTS SPECIFICATIONS [924296-19-5]

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Catalog

HY-50737A

Brand

MCE

CAS

924296-19-5

DESCRIPTION [924296-19-5]

Overview

MDL	MFCD28167759
Molecular Weight	275.26
Molecular Formula	C15H9N5O
SMILES	N#CC1=C(C#N)N=C2C(/C(C3=C2C=CC=C3)=N/OCC)=N1

For research use only. We do not sell to patients.

11 Publications Citing Use of MCE

Summary

DUB-IN-2 is a potent deubiquitinase inhibitor with an IC ₅₀ of 0.28 μM for USP8 ^[1] .

IC50 & Target

IC50: 0.28 μM (USP8) ^[1]

In Vitro

DUBs-IN-2 (compound 22 e) is a potent USP8 inhibitor with an IC ₅₀ of 0.28 μM, and has no effect on USP7, with an IC ₅₀ of >100 μM. DUBs-IN-2 inhibits the viability of HCT116 colon cell line and PC-3 prostate cancer cell line with IC ₅₀ values of 0.5-1.5 μM ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL ( 36.33 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.6329 mL	18.1646 mL	36.3293 mL
5 mM	0.7266 mL	3.6329 mL	7.2659 mL
10 mM	0.3633 mL	1.8165 mL	3.6329 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 50% PEG300 >> 50% saline

Solubility: 1.5 mg/mL (5.45 mM); Suspended solution; Need ultrasonic
2.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: 1 mg/mL (3.63 mM); Suspended solution; Need ultrasonic

* All of the co-solvents are available by MCE.

References

[1] Colombo M, et al. Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem. 2010 Apr 6;5(4):552-8.