[CAS NO. 950-99-2] 2,2,5,7,8-Pentamethyl-6-Chromanol

Name: 2,2,5,7,8-Pentamethyl-6-Chromanol
Brand: Arctom Scientific
SKU: HY-111024

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PRODUCTS SPECIFICATIONS [950-99-2]

Fulfillment

Catalog

HY-111024

Brand

MCE

CAS

950-99-2

DESCRIPTION [950-99-2]

Overview

MDL	-
Molecular Weight	220.31
Molecular Formula	C14H20O2
SMILES	OC1=C(C)C(C)=C2C(CCC(C)(C)O2)=C1C

For research use only. We do not sell to patients.

Summary

2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) is the anti-oxidant moiety of vitamin E (α-tocopherol). 2,2,5,7,8-Pentamethyl-6-Chromanol has potent androgen receptor (AR) signaling modulation and anti-cancer activity against prostate cancer cell lines ^[1] .

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL ( 1134.76 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.5391 mL	22.6953 mL	45.3906 mL
5 mM	0.9078 mL	4.5391 mL	9.0781 mL
10 mM	0.4539 mL	2.2695 mL	4.5391 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.08 mg/mL (9.44 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (9.44 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.08 mg/mL (9.44 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Kyriakopoulos CE, et al. A multicenter phase 1/2a dose-escalation study of the antioxidant moiety of vitamin E 2,2,5,7,8-pentamethyl-6-chromanol (APC-100) in men with advanced prostate cancer. Invest New Drugs. 2016 Apr;34(2):225-30.

Synonyms

2H-1-Benzopyran-6-ol, 3,4-dihydro-2,2,5,7,8-pentamethyl-

6-Chromanol, 2,2,5,7,8-pentamethyl-

3,4-Dihydro-2,2,5,7,8-pentamethyl-2H-1-benzopyran-6-ol

6-Hydroxy-2,2,5,7,8-pentamethylchroman

2,2,5,7,8-Pentamethyl-6-chromanol

2,2,5,7,8-Pentamethyl-6-hydroxychroman

TMC 5

Chromane C₁

Chromanol

α-C-1-Chromanol

Chroman C₁

NSC 226236

PMC

2,2,5,7,8-Pentamethyl-3,4-dihydrochromen-6-ol

APC 100