[CAS NO. 23496-41-5] Peimine
PRODUCTS SPECIFICATIONS [23496-41-5]
DESCRIPTION [23496-41-5]
Overview
| MDL | MFCD02259442 |
|---|---|
| Molecular Weight | 431.65 |
| Molecular Formula | C27H45NO3 |
| SMILES | [H][C@]12[C@]3([H])C[C@H](O)[C@@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])C[C@]([H])1[C@]5([H])CN6C[C@@H](C)CC[C@]([H])6[C@@](C)(O)[C@]([H])5CC2 |
Summary
Peimine(Dihydroisoimperialine; Verticine) is a natural compound with good anti-inflammatory effects in vivo. IC50 value: Target: Peimine (0-25 mg/L) significantly inhibited tumor necrosis factor (TNF)-α, interleukin (IL)-6, IL-1β, and increased IL-10 production. Furthermore, peimine significantly inhibited the phosphorylation of p38, ERK and c-jun N-terminal kinase (JNK) as well as decreased p65 and IκB.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 50 mg/mL ( 115.83 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.3167 mL | 11.5835 mL | 23.1669 mL |
| 5 mM | 0.4633 mL | 2.3167 mL | 4.6334 mL |
| 10 mM | 0.2317 mL | 1.1583 mL | 2.3167 mL |
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1.
References
- [1] Yi PF, et al. Peimine impairs pro-inflammatory cytokine secretion through the inhibition of the activation of NF-κB and MAPK in LPS-induced RAW264.7 macrophages. Immunopharmacol Immunotoxicol. 2013 Oct;35(5):567-72.
- [2] Chen K, Lv ZT, Zhou CH, et al. Peimine suppresses interleukin‑1β‑induced inflammation via MAPK downregulation in chondrocytes. Int J Mol Med. 2019;43(5):2241-2251.
Synonyms