[CAS NO. 509-15-9] Gelsemine
PRODUCTS SPECIFICATIONS [509-15-9]
DESCRIPTION [509-15-9]
Overview
| MDL | MFCD00082347 |
|---|---|
| Molecular Weight | 322.40 |
| Molecular Formula | C20H22N2O2 |
| SMILES | O=C1NC2=CC=CC=C2[C@]13[C@]4([H])[C@@]5([C@]6([H])C[C@H]3OC[C@@H]6[C@H]4N(C)C5)C=C |
Summary
Gelsemine, an alkaloid from the Chinese herb Gelsemium elegans , is effective in mitigating chronic pain. Antinociceptive effects.
In Vivo
Gelsemine is an effective agent for treatment of both neuropathic pain and sleep disturbance in partial sciatic nerve ligation (PSNL) mice. Gelsemine (4 mg/kg) exerts analgesic effects on PSNL-induced mechanical allodynia and thermal hyperalgesia. In PSNL mice, Gelsemine (2 and 4 mg/kg) increases the mechanical threshold for 4 h and prolonged the thermal latencies for 3 h. Furthermore, Gelsemine (4 mg/kg, administered at 6:30 AM) increases non-rapid eye movement (non-REM, NREM) sleep, decreases wakefulness, but does not affect rapid eye movement (REM) sleep during the first 3 h in PSNL mice
[1]
.
Immunohistochemical study shows that PSNL increases c-Fos expression in the neurons of the anterior cingulate cortex, and Gelsemine (4 mg/kg) decreases c-Fos expression by 58%
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
DMSO : ≥ 125 mg/mL ( 387.72 mM )
H 2 O : 5 mg/mL ( 15.51 mM ; ultrasonic and warming and heat to 60°C)
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.1017 mL | 15.5087 mL | 31.0174 mL |
| 5 mM | 0.6203 mL | 3.1017 mL | 6.2035 mL |
| 10 mM | 0.3102 mL | 1.5509 mL | 3.1017 mL |
Synonyms