[CAS NO. 50293-90-8] Levalbuterol hydrochloride
PRODUCTS SPECIFICATIONS [50293-90-8]
DESCRIPTION [50293-90-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 275.77 |
| Molecular Formula | C13H22ClNO3 |
| SMILES | CC(C)(NC[C@@H](C1=CC=C(C(CO)=C1)O)O)C.[H]Cl |
Summary
Levalbuterol ((R)-Albuterol) hydrochloride is a short-acting β2-adrenergic receptor agonist and the active (R)-enantiomer of Salbutamol. Levalbuterol hydrochloride is a more potent bronchodilator than Salbutamol and has the potential for the treatment of COPD [1] .
In Vitro
Levalbuterol (10 μM; 24 hours) hydrochloride induces
11β-HSD1
mRNA expression, however, it does not influence
11β-HSD2
expression in airway epithelial cells
[1]
.
Levalbuterol (10 μM; 24 hours) hydrochloride significantly reduces both LPS- and TNF-α-induced NF-κB activity while increasing GRE activation in an 11β-HSD1 dependent manner in a transformed mouse airway epithelial cell line
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
RT-PCR [1]
| Cell Line: | Murine Club (MTCC) cells |
| Concentration: | 10 μM |
| Incubation Time: | 24 hours |
| Result: | Increased 11β-HSD1 mRNA expression selectively. |
In Vivo
Levalbuterol (subcutaneous injection; 1 mg/kg; 14 days) hydrochloride significantly decreases pulmonary inflammation in OVA mice, demonstrated a decrease in eosinophilia and IgE [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | C57BL/6 female mice with a pulmonary allergic model [2] |
| Dosage: | 1 mg/kg |
| Administration: | Subcutaneous injection; 1 mg/kg; 14 days |
| Result: | Decreased pulmonary inflammation after OVA sensitization. |
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 100 mg/mL ( 362.62 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.6262 mL | 18.1311 mL | 36.2621 mL |
| 5 mM | 0.7252 mL | 3.6262 mL | 7.2524 mL |
| 10 mM | 0.3626 mL | 1.8131 mL | 3.6262 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (362.62 mM); Clear solution; Need ultrasonic
References
- [1] Randall MJ, et, al. Anti-inflammatory effects of levalbuterol-induced 11β-hydroxysteroid dehydrogenase type 1 activity in airway epithelial cells. Front Endocrinol (Lausanne). 2015 Jan 12;5:236.
- [2] Ferrada MA, et, al. (R)-albuterol decreases immune responses: role of activated T cells. Respir Res. 2008 Jan 14;9(1):3.