[CAS NO. 1005095-06-6] SIRT2-IN-11
PRODUCTS SPECIFICATIONS [1005095-06-6]
DESCRIPTION [1005095-06-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 318.41 |
| Molecular Formula | C21H22N2O |
| SMILES | O=C(C1=CC=C2NC(C3C(C4CCC3C4)C2=C1)C5=CC=CC=C5)N |
Summary
IC50 & Target
|
SIRT2 18.5 μM (IC 50 ) |
SIRT1 118.4 μM (IC 50 ) |
In Vitro
SIRT2-IN-11 (0-1000 μM) shows inhibitory effect of SIRT2-dependent deacetylation of MAL with an IC
50
value of 18.5 μM
[1]
.
SIRT2-IN-11 (0-1000 μM) weakly inhibits SIRT1 with an IC
50
value of 118.4 μM
[1]
.
SIRT2-IN-11 (0-20 μM; 8 h) induces cell apoptosis of lung cancer cells
[1]
.
SIRT2-IN-11 (20 μM; 6 h) increases p53 acetylation and expression levels of Cp53 target genes
CDKN1A
,
PUMA
and
NOXA
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
RT-PCR [1]
| Cell Line: | NSCLC cell lines |
| Concentration: | 20 μM |
| Incubation Time: | 6 hours |
| Result: | Increased the expression of CDKN1A, PUMA and NOXA. |
Apoptosis Analysis [1]
| Cell Line: | A549 cell line |
| Concentration: | 0, 0.5, 1, 5, 10 and 20 μM |
| Incubation Time: | 24 hours |
| Result: | Mildly increased apoptosis of A549 cells, but when combined treatment with etoposide caused a marked increase in apoptosis. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.