[CAS NO. 157397-06-3] TX-1123
PRODUCTS SPECIFICATIONS [157397-06-3]
DESCRIPTION [157397-06-3]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 312.40 |
| Molecular Formula | C20H24O3 |
| SMILES | O=C1/C(C(C=C1)=O)=C\C2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2 |
Summary
TX-1123 is a potent protein tyrosine kinase (PTK) inhibitor for Src , eEF2-K, and PKA , and EGFR-K/PKC. TX-1123 is a cyclo-oxygenase (COX) inhibitor with IC 50 values of 1.16 μM and 15.7 μM for COX2 and COX1, respectively. TX-1123 has low mitochondrial toxicity. TX-1123 can be used in research of cancer [1] [2] .
IC50 & Target
|
COX-2 1.16 nM (IC 50 ) |
COX-1 15.7 μM (IC 50 ) |
In Vitro
TX-1123 (NIH3T3 cells) inhibits Src-K, eEF2-K, PKA, PKC, EGFR-k with IC
50
values of 2.2, 3.2, 9.6, 320, and 320 μM, respectively
[1]
.
TX-1123 (mitochondrial suspension) has a weaker mitochondrial toxicity and ATP-synthesis inhibitory activities with an IC
50
value of 5 μM
[1]
.
TX-1123 (0-1000 μM; 48 h) has antitumor activity with IC
50
values of 3.66, 39, and 57 μM for HepG2, HCT116, and Rat hepatocytes, respectively
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay [1]
| Cell Line: | HepG2, HCT116, and Rat hepatocytes |
| Concentration: | 0-1000 μM |
| Incubation Time: | 48 hours |
| Result: | Inhibited tumor cell growth in a dose-dependent manner. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References
- [1] Hori H, et, al. TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity. Bioorg Med Chem. 2002 Oct;10(10):3257-65.
- [2] Ohkura K, et, al. Interactive Analysis of TX-1123 with Cyclo-oxygenase: Design of COX2 Selective TX Analogs. Anticancer Res. 2017 Jul;37(7):3849-3854.