[CAS NO. 1848232-20-1] GSK2226649A
PRODUCTS SPECIFICATIONS [1848232-20-1]
DESCRIPTION [1848232-20-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 378.81 |
| Molecular Formula | C15H12ClFN6OS |
| SMILES | O=C(N)C1=C(F)C=CC=C1NC2=NC(NCC3=NC=CS3)=NC=C2Cl |
Summary
GSK2226649A (compound 2) is a novel activator of satellite cell proliferation and enhanced repair of damaged muscle [1] .
In Vitro
GSK2226649A (compound 2) (0.1-10μM) can dose-dependently promote the proliferation of muscle stem cells, and can effectively accelerate the repair of damaged skeletal muscle in an in vivo mouse model of skeletal muscle injury
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
The pharmacokinetic parameters of GSK2226649A(compound 2) in mice
| Dose(mg) | route | C max (ng/mL) | T max (hrs) | T 1/2 (hrs) | AUC 0-inf (h*ng/mL) |
| 30 | oral | 1384 | 0.5 | 1.6 | 1720 |
| 30 | SC | 1783 | 1.0 | 6.1 | 12077 |
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
