[CAS NO. 204981-48-6] CP-195543
PRODUCTS SPECIFICATIONS [204981-48-6]
DESCRIPTION [204981-48-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 428.40 |
| Molecular Formula | C24H19F3O4 |
| SMILES | O=C(O)C1=CC=C(C(F)(F)F)C=C1C2=CC=C3[C@H](O)[C@@H](CC4=CC=CC=C4)COC3=C2 |
Summary
CP-195543 is a potent, selective and orally active leukotriene B4 (LTB4) receptor antagonist with IC 50 s of 6.8, 37.0 nM for human neutrophils and murine spleen membranes, respectively. CP-195543 blocks CD11b up-regulation. CP-195543 inhibits LTB4-mediated neutrophil infiltration [1] .
IC50 & Target
|
LTB 4 |
In Vitro
CP-195543 inhibits human and mouse neu-trophil chemotaxis mediated by LTB4 with IC
50
values of 2.4 nM, 7.5 nM, respectively
[1]
.
CP-195543 (0.1 nM-10 µM; 60 min) blocks CD11b up-regulation on human neutrophils (HN) and murine neutrophils with IC
50
s of 270, 420 nM for human monocytes and eosinophils, respectively
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
CP-195543 (0.01, 0.1, 1, 10 mg/kg for guinea pig; 0.01, 0.1, 1, 10, 100 mg/kg for mice; P.o.; 1 h before injection of LTB4) inhibits LTB4-mediated neutrophil infiltration in guinea pigskin in a dose-dependent manner [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Guinea pig (Injection of LTB4 10, 30, 100 ng/site; injected intradermally) [1] |
| Dosage: | 0.01, 0.1, 1, 10 mg/kg |
| Administration: | P.o.; 1 h before injection of LTB4 |
| Result: | Inhibited LTB4-mediated neutrophil infiltration in guinea pigskin in a dose-dependent manner. |
| Animal Model: | Mice (Injection of LTB4 100 ng/site; injected intradermally) [1] |
| Dosage: | 0.01, 0.1, 1, 10, 100 mg/kg |
| Administration: | P.o.; 1 h before injection of LTB4 |
| Result: | Inhibited LTB4-mediated neutrophil infiltration in guinea pigskin in a dose-dependent manner. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.