[CAS NO. 2738606-83-0] A2A receptor antagonist 3
PRODUCTS SPECIFICATIONS [2738606-83-0]
DESCRIPTION [2738606-83-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 454.52 |
| Molecular Formula | C26H26N6O2 |
| SMILES | CC(C)(O)[C@H](C)NC(C1=NC2=C(C3=CC(C)=NC(C)=C3)C(C4=CC(C#N)=CC=C4)=NN2C=C1)=O |
Summary
A2A receptor antagonist 3 (Example 92) is an adenosine A2a receptor antagonist with a K i of 0.4 nM. A2A receptor antagonist 3 also binds to A2b, A1 and A3 receptor with K i s of 37, 107 and 1467 nM, respectively [1] .
IC50 & Target
|
A2AR 0.4 nM (Ki) |
A2BR 37 nM (Ki) |
A1R 107 nM (Ki) |
A3R 1467 nM (Ki) |
In Vitro
A2A receptor antagonist 3 (Example 92) (24 h) inhibits CD3/CD28 stimulated IL-2 release with an IC
50
of 0.004 μM
[1]
.
A2A receptor antagonist 3 (20 min) inhibits pCREB in CD8+T cells in human whole blood with an IC
50
of 0.02 μM
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
References