[CAS NO. 2757672-69-6] (S)-GFB-12811

Name: (S)-GFB-12811
Brand: Arctom Scientific
SKU: AS1031270

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PRODUCTS SPECIFICATIONS [2757672-69-6]

Distributor

Catalog

AS1031270

Brand

Arctom Scientific

CAS

2757672-69-6

DESCRIPTION [2757672-69-6]

Overview

MDL	-
Molecular Weight	449.44
Molecular Formula	C22H23F4N5O
SMILES	C[C@@](C1=NC2=C(C=NC(NC3=C(F)C=NC(C(F)(F)F)=C3)=C2)C=C1)(C4CCN(CC4)C)O

For research use only. We do not sell to patients.

Summary

(S)-GFB-12811 (compound 596) is a potent and selective CDK5 inhibitor, with an IC ₅₀ value less than 10 nM. (S)-GFB-12811 can be used in the research of cell cycle progression, neuronal development, tumorigenesis ^[1] .

IC50 & Target

CDK5

<10 nM (IC ₅₀ )

CDK2

100 nM~1 μ nM (IC ₅₀ )

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

References

[1] Malojcic Goran, et al. Substituted 1,6-naphthyridines as inhibitors of CDK5 and their preparation. Patent WO2022011274.