[CAS NO. 66537-55-1] MK771

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PRODUCTS SPECIFICATIONS [66537-55-1]

Catalog

AS1039891

Brand

Arctom Scientific

CAS

66537-55-1

DESCRIPTION [66537-55-1]

Overview

MDL	-
Molecular Weight	394.45
Molecular Formula	C16H22N6O4S
SMILES	O=C(N[C@H](C(N1CSC[C@@H]1C(N)=O)=O)CC2=CNC=N2)[C@@H](N3)CCCC3=O

For research use only. We do not sell to patients.

Summary

MK771 is a thyrotrophin-releasing hormone analog. MK771 induces blinking and forepaw licking. MK771 has the potential for the research of morphine abstinence syndrome ^[1] ^[2] .

In Vivo

MK771 (5 mg/kg; i.p.) induces blinking and forepaw licking in mice ^[1] .
MK771 (10 ng-10 µg/mouse; i.c.v.) produces a hyperthermic response in mice ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	20-30 g, male MF1 mice ^[1]
Dosage:	5 mg/kg
Administration:	I.p.
Result:	Induced blinking and forepaw licking in both acutely isolated and paired mice.

Animal Model:	20-30 g, male MF1 mice ^[1]
Dosage:	0.25-60 mg/kg
Administration:	I.p.
Result:	Induced blinking was bell-shaped with an ED ₅₀ value of 1.72 mg/kg.

Animal Model:	25-30 g, Male Swiss-Webster mice ^[2]
Dosage:	10 ng-10 µg/mouse
Administration:	I.c.v.
Result:	Produced a hyperthermic response for 4 h followed by a return to normal temperature.

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