[CAS NO. 66395-03-7] Chloranthalactone B
PRODUCTS SPECIFICATIONS [66395-03-7]
DESCRIPTION [66395-03-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 244.29 |
| Molecular Formula | C15H16O3 |
| SMILES | C[C@@]12[C@@]3([H])[C@]4(O3)C(C[C@@]1([H])C([C@]5([H])[C@@]2([H])C5)=C)=C(C(O4)=O)C |
Summary
In Vitro
Chloranthalactone B (6.25-50 µM; 30 min) has anti-inflammatory effects in LPS-stimulated RAW264.7 cells and inhibits NO production
[1]
.
Chloranthalactone B (25 and 50 µM; 30 min) inhibits inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), tumor necrosis factor α (TNF-α), and interleukin-1β (IL-1β) expression in LPS-treated RAW264.7 cells
[1]
.
Chloranthalactone B (25 and 50 µM; RAW264.7 cells) inhibits LPS-induced AP-1 activation in a concentration-dependent manner
[1]
.
Chloranthalactone B (25 and 50 µM; 30 min; RAW264.7 cells) inhibits the phosphorylation of ERK, JNK, and p38 in RAW264.7 cells
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Western Blot Analysis [1]
| Cell Line: | RAW264.7 cells |
| Concentration: | 25 and 50 µM |
| Incubation Time: | 30 min |
| Result: |
Inhibited the expression of iNOS, TNF-α, COX-2, and IL-1β in a dose-dependent manner.
Inhibited the phosphorylation of ERK, JNK, and p38 in RAW264.7 cells. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.