[CAS NO. 1213777-80-0] Triphen diol
PRODUCTS SPECIFICATIONS [1213777-80-0]
DESCRIPTION [1213777-80-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 348.39 |
| Molecular Formula | C22H20O4 |
| SMILES | OC1=CC=C2C(OC[C@H](C3=CC=C(O)C=C3)[C@@H]2C4=CC=C(OC)C=C4)=C1 |
Summary
In Vitro
Triphen diol (0-10 μM, 48-120 h) can inhibit the proliferation of pancreatic cells and induce apoptosis, with an IC
50
value of 8 μM for HPAC and PANC-1 cells and an IC
50
value of 0.8 for MIAPaCa-2 cells μM
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Apoptosis Analysis [1]
| Cell Line: | Human pancreatic cell lines HPAC, MIAPaCa-2, and PANC-1 |
| Concentration: | 10 μM |
| Incubation Time: | 48 h |
| Result: |
Induced caspase-dependent apoptosis in MIAPaCa-2 and PANC-1 cells, 60% of the cells were in the early stage of apoptosis, and 30% of the cells were in the late stage of apoptosis.
Reduced Bcl-2 levels in MIAPaCa-2 and HPAC cell lines. |
In Vivo
Triphen diol (50 mg/kg, oral gavage, daily, 15 days) can significantly inhibit tumor proliferation in male Balb/c nude mice transplanted with MIAPaCa2 cell line, and can be combined with gemcitabine to show better efficacy
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.