[CAS NO. 2368901-31-7] BRM/BRG1 ATP Inhibitor-3
PRODUCTS SPECIFICATIONS [2368901-31-7]
DESCRIPTION [2368901-31-7]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 503.64 |
| Molecular Formula | C26H25N5O2S2 |
| SMILES | O=C(C1=CC=C(C=C1)N)N[C@@H](CCSC)C(NC2=NC(C3=CC(C4=CC=NC=C4)=CC=C3)=CS2)=O |
Summary
BRM/BRG1 ATP Inhibitor-3 is a BRG1/BRM inhibitor. BRM/BRG1 ATP Inhibitor-3 inhibits BRM and BRG1 with IC 50 values of 10.4 nM and 19.3 nM, respectively. BRM/BRG1 ATP Inhibitor-3 can be used for the research of cancers and BAF complex-related disorders [1] .
IC50 & Target
IC50: 10.4 nM (BRM); 19.3 nM (BRG1) [1] .
In Vitro
BRM/BRG1 ATP Inhibitor-3 has inhibitory activity for BRM and BRG1 with IC
50
values of 10.4 nM and 19.3 nM, respectively
[1]
.
BRM/BRG1 ATP Inhibitor-3 (0.01-10 μM) has inhibition for cell proliferation in several cancer cell lines
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay [1]
| Cell Line: | Uveal melanoma cell lines (92-1 , MP41 , MP38, MP46), prostate cancer cell lines (LNCAP), lung cancer cell lines (NCI-H1299), and immortalized embryonic kidney lines (HEK293T) |
| Concentration: | 0-10 μM |
| Incubation Time: | 3 days |
| Result: | Inhibited cell proliferation of uveal melanoma cell line 92-1 and MP41. |
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.