[CAS NO. 13721-39-6] Sodium orthovanadate
PRODUCTS SPECIFICATIONS [13721-39-6]
DESCRIPTION [13721-39-6]
Overview
| MDL | MFCD00003511 |
|---|---|
| Molecular Weight | 183.91 |
| Molecular Formula | Na3O4V |
| SMILES | [O].[Na].[V] |
2 Publications Citing Use of MCE
Summary
Sodium orthovanadate is an inhibitor of protein tyrosine phosphatases , alkaline phosphatases and a number of ATPases, most likely acting as a phosphate analogue.
IC50 & Target
PPTPase [1] .
In Vitro
In the presence of oxidizing agents vanadium ions exist as the hydrated monomer of Sodium orthovanadate (vanadate: HVO4 2- or H2VO 4- ) at micromolar concentations near neutral pH. Sodium orthovanadate (vanadate) also begins to polymerize at concentrations greater than 0.1 mM at neutral pH. The yellow-orange solutions of decavanadate can be converted to the colorless solutions of monomeric Sodium orthovanadate (vanadate) by dilution after a period of many hours. The process is hastened by boiling at pH 10, which encourages the kinetically sluggish depolymerization process [1] . Sodium orthovanadate could alter the phosphorylation status of ASK1 at serine 83 and threonine 845 induced by ischemia. Sodium orthovanadate could increase the tyrosine posphorylation of PTEN and further inhibit the activation of ASK1 via activating Akt during cerebral ischemia [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H 2 O : 8.33 mg/mL ( 45.29 mM ; Need ultrasonic)
DMSO : < 1 mg/mL (ultrasonic;warming;heat to 80°C) (insoluble or slightly soluble)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 5.4374 mL | 27.1872 mL | 54.3744 mL |
| 5 mM | 1.0875 mL | 5.4374 mL | 10.8749 mL |
| 10 mM | 0.5437 mL | 2.7187 mL | 5.4374 mL |
-
1.
Add each solvent one by one: PBS
Solubility: 16.67 mg/mL (90.64 mM); Clear solution; Need ultrasonic and warming and heat to 60°C
Synonyms