[CAS NO. 17302-61-3] Poloxime

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PRODUCTS SPECIFICATIONS [17302-61-3]

Catalog

AS179467

Brand

Arctom Scientific

CAS

17302-61-3

DESCRIPTION [17302-61-3]

Overview

MDL	-
Molecular Weight	179.22
Molecular Formula	C10H13NO2
SMILES	CC1=CC(C(C(C)C)=C/C1=N\O)=O

For research use only. We do not sell to patients.

Summary

Poloxime, a hydrolysis product of poloxin, is a non-ATP-competitive Plk1 inhibitor, with moderate Plk1 inhibitory activity.

IC50 & Target

PLK1

In Vitro

Poloxime (100 μM) inhibits phosphopeptide binding to polo-box domain (PBD) of polo-like kinase 1 (Plk1) ^[2] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 557.97 mM )

H ₂ O : < 0.1 mg/mL (insoluble)

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.5797 mL	27.8987 mL	55.7973 mL
5 mM	1.1159 mL	5.5797 mL	11.1595 mL
10 mM	0.5580 mL	2.7899 mL	5.5797 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (13.95 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (13.95 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (13.95 mM); Clear solution

* All of the co-solvents are available by MCE.