[CAS NO. 133865-88-0] Ralfinamide

Ships within

Stock

Price

Qty

Total

$0.00

Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis

request a quote

If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [133865-88-0]

Catalog

AS267983

Brand

Arctom Scientific

CAS

133865-88-0

DESCRIPTION [133865-88-0]

Overview

MDL	MFCD08272558
Molecular Weight	302.34
Molecular Formula	C17H19FN2O2
SMILES	C[C@H](NCC1=CC=C(OCC2=CC=CC=C2F)C=C1)C(N)=O

For research use only. We do not sell to patients.

1 Publications Citing Use of MCE

[1]Acta Pharmacol Sin. 2021 Aug;42(8):1235-1247.

Summary

Ralfinamide (FCE-26742A) is an orally available Na ⁺ blocker derived from α-aminoamide, with function of suppressing pain ^[1] ^[2] .

IC50 & Target

Na ⁺ channel ^[1]

In Vivo

Ralfinamide (30 mg/kg, 60 mg/kg; p.o.; twice daily; 42 days) treated with Ralfinamide (80 mg/kg; p.o.; twice daily; 7 days) preoperatively suppresses neuropathic pain ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	81 adult male Sprague–Dawley male rats (260–460 g) ^[1]
Dosage:	80 mg/kg (7 days preoperatively), 30 mg/kg, 60 mg/kg (postoperative)
Administration:	Oral gavage; twice daily; until postoperative day 42
Result:	Suppressed neuropathic pain.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT01019824	Newron Pharmaceuticals SPA\|Parexel\|CliniRx	Pain	March 20, 2009	Phase 3
NCT00736151	Newron Pharmaceuticals SPA	Neuropathic Pain	May 2004	Phase 2

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 125 mg/mL ( 413.44 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3075 mL	16.5377 mL	33.0753 mL
5 mM	0.6615 mL	3.3075 mL	6.6151 mL
10 mM	0.3308 mL	1.6538 mL	3.3075 mL

* Please refer to the solubility information to select the appropriate solvent.

References

Synonyms

Propanamide, 2-[[[4-[(2-fluorophenyl)methoxy]phenyl]methyl]amino]-, (2S)-

Propanamide, 2-[[[4-[(2-fluorophenyl)methoxy]phenyl]methyl]amino]-, (S)-

(2S)-2-[[[4-[(2-Fluorophenyl)methoxy]phenyl]methyl]amino]propanamide

(S)-2-[[4-[(2-Fluorobenzyl)oxy]benzyl]amino]propanamide

Priralfinamide

(2S)-2-[[4-[(2-Fluorophenyl)methoxy]phenyl]methylamino]propanamide