[CAS NO. 29876-14-0] Nicotredole
PRODUCTS SPECIFICATIONS [29876-14-0]
DESCRIPTION [29876-14-0]
Overview
| MDL | MFCD00841846 |
|---|---|
| Molecular Weight | 265.31 |
| Molecular Formula | C16H15N3O |
| SMILES | O=C(C1=CC=CN=C1)NCCC2=CNC3=C2C=CC=C3 |
Summary
In Vitro
Nicotredole inhibits prostaglandin synthetase activity in vitro [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Nicotredole produces antiinflammatory effects in carrageenin-induced rat paw oedema
[1]
.
Nicotredole reverses pyrogen-induced hyperthermia in rats, elicits analgesic effects in rats, prolongs the time of hexobarbital sleep in rats and inhibits locomotor activity in rats and mice
[1]
.
Nicotredole (i.p.) has LD50s of 1260 mg/kg and 1980 mg/kg for male rats and male mice, respectively
[1]
.
Nicotredole (p.o.) has LD50s of 8.5 g/kg and 9.3 g/kg for male rats and male mice, respectively
[1]
.
Nicotredole (25 mg/kg; p.o. or i.p.) undergoes fast absorption (t
1/2
=4.92-17.5 min) and elimination (t
1/2
=55.72-74.52 min), can reach C
max
(11-13 μg/cm
3
) after 30 min, and gives AUC values in the range of 21.40-27.30 (μg•h/cm
3
)
[2]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 25 mg/mL ( 94.23 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.7692 mL | 18.8459 mL | 37.6918 mL |
| 5 mM | 0.7538 mL | 3.7692 mL | 7.5384 mL |
| 10 mM | 0.3769 mL | 1.8846 mL | 3.7692 mL |
References
- [1] Herman ZS, et, al. Basic pharmacological properties of a novel antiinflammatory drug tryptamide. Pol J Pharmacol Pharm. Nov-Dec 1987;39(6):729-36.
- [2] Szumiło H. Pharmacokinetics of tryptamide following oral and intraperitoneal administration in rats. Acta Pol Pharm. 1990;47(1-2):19-22.
- [3] Kulig D, et, al. A comparison of anti-inflammatory, analgesic and ulcerogenic action of tryptamide, ibuprofen and piroxicam. Pol J Pharmacol Pharm. Nov-Dec 1987;39(6):769-72.
Synonyms