[CAS NO. 1370256-78-2] SKLB4771 (FLT3-IN-1)
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PRODUCTS SPECIFICATIONS [1370256-78-2]
Catalog
AS865977
Brand
Arctom Scientific
CAS
1370256-78-2
DESCRIPTION [1370256-78-2]
Overview
| MDL | MFCD28900746 |
|---|---|
| Molecular Weight | 537.66 |
| Molecular Formula | C25H27N7O3S2 |
| SMILES | O=C(NC1=CC=C(C)C=C1)NC2=NN=C(SC3=C4C=CC(OCCCN5CCOCC5)=CC4=NC=N3)S2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8599 mL | 9.2996 mL | 18.5991 mL |
| 5 mM | 0.3720 mL | 1.8599 mL | 3.7198 mL |
| 10 mM | 0.1860 mL | 0.9300 mL | 1.8599 mL |
| 50 mM | 0.0372 mL | 0.1860 mL | 0.3720 mL |
Description
SKLB4771 is a potent and selective inhibitor of human receptor-type tyrosine-protein kinase with IC50 of 10 nM.
Targets
| FLT3 [1] (Cell-free assay) |
| 10 nM |
In vitro
SKLB4771 just weakly inhibits Aurora A, FMS, FLT4, and c-Kit (IC50s: 1.5 μM, 2.8 μM, 3.7 μM, and 6.8 μM, respectively). SKLB4771 displays almost no inhibitory activity against the other 13 selected protein kinases. SKLB4771 potently inhibits the growth of MV4-11 cells that express FLT3-ITD, with an IC50 value of 0.006 μM. SKLB4771 just exhibits very weak inhibitory activity against human T lymphoma Jurkat cells, human Burkitt’s lymphoma Ramos cells, human lung cancer PC-9 and H292 cells, and human epithelial carcinoma A431 cells (IC50: 3.05 μM, 6.25 μM, 3.72 μM, 6.94 μM, and 8.91 μM, respectively)..
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