[CAS NO. 1394854-52-4] GSK-J2
PRODUCTS SPECIFICATIONS [1394854-52-4]
DESCRIPTION [1394854-52-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 389.45 |
| Molecular Formula | C22H23N5O2 |
| SMILES | O=C(O)CCNC1=NC(C2=CC=CN=C2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1 |
1 Publications Citing Use of MCE
Summary
GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.
In Vitro
GSK-J2 is an isomer of GSK-J1, and shows poor activity towards KDM6A and KDM6B, with IC 50 of > 100 μM and 49 μM, respectively [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : ≥ 42 mg/mL ( 107.84 mM )
* "≥" means soluble, but saturation unknown.
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.5677 mL | 12.8386 mL | 25.6772 mL |
| 5 mM | 0.5135 mL | 2.5677 mL | 5.1354 mL |
| 10 mM | 0.2568 mL | 1.2839 mL | 2.5677 mL |
References
Synonyms