[CAS NO. 1401963-15-2]  Mc-MMAD

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PRODUCTS SPECIFICATIONS [1401963-15-2]

Catalog
AS866599
Brand
Arctom Scientific
CAS
1401963-15-2

DESCRIPTION [1401963-15-2]

Overview

MDLMFCD26960951
Molecular Weight964.26
Molecular FormulaC51H77N7O9S
SMILESO=C1N(CCCCCC(N(C)[C@H](C(N[C@@H](C(C)C)C(N(C)[C@]([C@@H](C)CC)([H])[C@@H](CC(N2[C@H]([C@H](OC)[C@H](C(N[C@@H](CC3=CC=CC=C3)C4=NC=CS4)=O)C)CCC2)=O)OC)=O)=O)C(C)C)=O)C(C=C1)=O

For research use only. We do not sell to patients.

Summary

Mc-MMAD is a protective group (maleimidocaproyl)-conjugated MMAD. MMAD is a potent tubulin inhibitor. Mc-MMAD is a drug-linker conjugate for ADC.


IC50 & Target

Auristatin


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years

* The compound is unstable in solutions, freshly prepared is recommended.


Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL ( 103.71 mM )

* "≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0371 mL 5.1853 mL 10.3706 mL
5 mM 0.2074 mL 1.0371 mL 2.0741 mL
10 mM 0.1037 mL 0.5185 mL 1.0371 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (2.59 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (2.59 mM); Clear solution

* All of the co-solvents are available by MCE.