[CAS NO. 1261590-48-0]  Duvelisib(Renantiomer)

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PRODUCTS SPECIFICATIONS [1261590-48-0]

Store
Catalog
AS947286
Brand
Arctom Scientific
CAS
1261590-48-0

DESCRIPTION [1261590-48-0]

Overview

MDLMFCD30187518
Molecular Weight416.86
Molecular FormulaC22H17ClN6O
SMILESClC1=C(C2=O)C(C=C([C@H](NC3=NC=NC4=C3N=CN4)C)N2C5=CC=CC=C5)=CC=C1

For research use only. We do not sell to patients.

Summary

Duvelisib R enantiomer is a PI3K inhibitor, which is the less active enantiomer of Duvelisib.


IC50 & Target

PI3K


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 239.89 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3989 mL 11.9944 mL 23.9889 mL
5 mM 0.4798 mL 2.3989 mL 4.7978 mL
10 mM 0.2399 mL 1.1994 mL 2.3989 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.00 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.38 mg/mL (5.71 mM); Clear solution

* All of the co-solvents are available by MCE.