[CAS NO. 1000578-26-6] AS19
PRODUCTS SPECIFICATIONS [1000578-26-6]
DESCRIPTION [1000578-26-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 283.41 |
| Molecular Formula | C18H25N3 |
| SMILES | CC1=C(C2=CC=CC3=C2CC[C@H](N(C)C)C3)C(C)=NN1C |
Summary
AS19 is a potent, selective 5-HT 7 receptor agonist with an IC 50 value of 0.83 nM and a K i of 0.6 nM. AS19 is selective for 5-HT 7 over 5-HT 1A , 5-HT 1B , 5-HT 1D , and 5-HT 5A receptors ( K i s = 89.7 nM, 490 nM, 6.6 nM and 98.5 nM, respectively). AS19 enhances memory consolidation and reverses Scopolamine- or Dizocilpine-induced amnesia [1] [2] [3] .
IC50 & Target
|
Human 5-HT 7 Receptor 0.83 nM (IC 50 ) |
Human 5-HT 7 Receptor 0.6 nM (Ki) |
5-HT 1A Receptor 89.7 nM (Ki) |
5-HT 1B Receptor 490 nM (Ki) |
5-HT 1D Receptor 6.6 nM (Ki) |
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|
5-HT 5 Receptor 98.5 nM (Ki) |
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In Vitro
The proliferation of T-cell from parachlorophenylalanine-treated mice is significantly reduced, addition of AS19 (1 μM) completely restores T-cell proliferation after 48 hours [2] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
AS19 (0.5-10 mg/kg; subcutaneous injection; for 24 hours; male Wistar rats) treatment improves memory consolidation in an autoshaping Pavlovian/instrumental learning task [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Male Wistar rats (12-week-old) with autoshaping Pavlovian/instrumental learning task [1] |
| Dosage: | 0.5 mg/kg, 1 mg/kg, 5 mg/kg, 10 mg/kg |
| Administration: | Subcutaneous injection; for 24 hours |
| Result: | Enhanced memory formation in an autoshaping Pavlovian/instrumental learning task. |
Appearance
Oil
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 352.85 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.5285 mL | 17.6423 mL | 35.2846 mL |
| 5 mM | 0.7057 mL | 3.5285 mL | 7.0569 mL |
| 10 mM | 0.3528 mL | 1.7642 mL | 3.5285 mL |
References
- [1] Perez-García GS, et al. Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task. Behav Brain Res. 2005 Aug 30;163(1):136-40.
- [2] León-Ponte M, et al. Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor. Blood. 2007 Apr 15;109(8):3139-46.
- [3] Brenchat A, et al. 5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice. Pain. 2009 Feb;141(3):239-47.
Synonyms