[CAS NO. 101187-39-7]  Azido-PEG3-azide

Ships within Stock Price Qty Total
$0.00
$0.00
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:

PRODUCTS SPECIFICATIONS [101187-39-7]

Catalog
AS956131
Brand
Arctom Scientific
CAS
101187-39-7

DESCRIPTION [101187-39-7]

Overview

MDLMFCD03425545
Molecular Weight244.25
Molecular FormulaC8H16N6O3
SMILES[N-]=[N+]=NCCOCCOCCOCCN=[N+]=[N-]

For research use only. We do not sell to patients.

Summary

Azido-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1] .


IC50 & Target

PEGs


In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Liquid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 409.42 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.0942 mL 20.4708 mL 40.9417 mL
5 mM 0.8188 mL 4.0942 mL 8.1883 mL
10 mM 0.4094 mL 2.0471 mL 4.0942 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.5 mg/mL (10.24 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (10.24 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.5 mg/mL (10.24 mM); Clear solution

* All of the co-solvents are available by MCE.