[CAS NO. 1141802-49-4] LUF5771
PRODUCTS SPECIFICATIONS [1141802-49-4]
DESCRIPTION [1141802-49-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 357.44 |
| Molecular Formula | C24H23NO2 |
| SMILES | O=C(NC1CCCC1)OC2=CC(C3=CC=CC=C3)=CC(C4=CC=CC=C4)=C2 |
Summary
LUF5771 is a potent allosteric recombinant luteinizing hormone ( recLH ) and Org 43553 inhibitor. LUF5771 is able to partially activate the LH receptor with low efficacy [1] .
IC50 & Target
recLH and Org 43553 [1]
In Vitro
LUF5771 (1 µM or 10 µM) allosteric inhibition is concentration-dependent. LUF5771 significantly increases radioligand dissociation. LUF5771 probably binds to the seven transmembrane domain like Org 43553 does. LUF5771 (10 µM) alone is able to partially activate the LH receptor by 31±4% [1] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 100 mg/mL ( 279.77 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.7977 mL | 13.9884 mL | 27.9767 mL |
| 5 mM | 0.5595 mL | 2.7977 mL | 5.5953 mL |
| 10 mM | 0.2798 mL | 1.3988 mL | 2.7977 mL |
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1.
Add each solvent one by one: 10% DMSO >> 90% corn oil
Solubility: ≥ 2.5 mg/mL (6.99 mM); Clear solution