[CAS NO. 1164500-72-4] ML 145
PRODUCTS SPECIFICATIONS [1164500-72-4]
DESCRIPTION [1164500-72-4]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 482.57 |
| Molecular Formula | C24H22N2O5S2 |
| SMILES | CC(/C=C(S1)/C(N(CCCC(NC2=CC(O)=C(C(O)=O)C=C2)=O)C1=S)=O)=C\C3=CC=CC=C3 |
Summary
IC50 & Target
IC50/EC50: 20.1 nM (GPR35), 21.7 μM (GPR55) [1]
In Vitro
ML 145 (10 μM) also fully blocks internalization of human FLAG-GPR35-eYFP in response to varying concentrations of Zaprinast, Cromolyn disodium, and Pamoate
[2]
.
ML 145 is either without effect (mouse) or displays only a small and apparently noncompetitive inhibitory effect (rat) at the rodent orthologs
[2]
.
ML 145 acts as a competitive antagonist for a number of agonists at human GPR35 and has an IC
50
value against EC
80
concentrations of various GPR35 agonists in the region of 20 nM
[1]
.
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance
Solid
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Powder | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
DMSO : 50 mg/mL ( 103.61 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 2.0722 mL | 10.3612 mL | 20.7224 mL |
| 5 mM | 0.4144 mL | 2.0722 mL | 4.1445 mL |
| 10 mM | 0.2072 mL | 1.0361 mL | 2.0722 mL |
-
1.
References
- [1] Heynen-Genel S, et al. Selective GPR35 Antagonists - Probes 1 & 2. National Center for Biotechnology Information (US); 2010-2010 Feb 28.
- [2] Laura Jenkins, et al. Antagonists of GPR35 display high species ortholog selectivity and varying modes of action. J Pharmacol Exp Ther. 2012 Dec;343(3):683-95.