[CAS NO. 120166-69-0] R59949
Please click "REQUEST A QUOTE" button if you need other sizes or
custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis,
please:
PRODUCTS SPECIFICATIONS [120166-69-0]
Catalog
AS959317
Brand
Arctom Scientific
CAS
120166-69-0
DESCRIPTION [120166-69-0]
Overview
| MDL | MFCD00069258 |
|---|---|
| Molecular Weight | 489.58 |
| Molecular Formula | C28H25F2N3OS |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0426 mL | 10.2128 mL | 20.4257 mL |
| 5 mM | 0.4085 mL | 2.0426 mL | 4.0851 mL |
| 10 mM | 0.2043 mL | 1.0213 mL | 2.0426 mL |
| 50 mM | 0.0409 mL | 0.2043 mL | 0.4085 mL |
Description
R59949, a inhibitor with an IC50 of 300 nM, inhibits inducible nitric oxide production through decreasing transplasmalemmal L-arginine uptake in vascular smooth muscle cells. R59949 strongly inhibits type I DGK a and γ, and moderately attenuates type II DGK θ and κ.
Targets
| DKG [1] |
| 0.3 μM |
In vitro
R59949 is a pan diacylglycerol kinase (DGK) inhibitor, which inhibits inducible NO production through decreasing transplasmalemmal L-arginine uptake in rat aortic smooth muscle cells (RASMCs).
References
Powered by Arctom Copyright © 2026 Arctom.
All rights reserved.