[CAS NO. 1213669-91-0] L-838417-d 9

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PRODUCTS SPECIFICATIONS [1213669-91-0]

Catalog

AS959610

Brand

Arctom Scientific

CAS

1213669-91-0

DESCRIPTION [1213669-91-0]

Overview

MDL	-
Molecular Weight	408.45
Molecular Formula	C19H10D9F2N7O
SMILES	CN1N=CN=C1COC(C(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=C2)=NN3C2=NN=C3C4=CC(F)=CC=C4F

For research use only. We do not sell to patients.

Summary

L-838417-d ₉ is the deuterium labeled L-838417. L-838417 is a subtype-selective GABAA positive allosteric modulator, acting as a partial agonist at α2, α3 and α5 subtypes[1].

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL ( 30.60 mM ; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4483 mL	12.2413 mL	24.4826 mL
5 mM	0.4897 mL	2.4483 mL	4.8965 mL
10 mM	0.2448 mL	1.2241 mL	2.4483 mL

* Please refer to the solubility information to select the appropriate solvent.

References

[1] Hofmann M, et al. Assessment of the effects of NS11394 and L-838417, α2/3 subunit-selective GABA(A) [corrected] receptor-positive allosteric modulators, in tests for pain, anxiety, memory and motor function [published correction appears in Behav Pharmacol. 2013 Apr;24(2):153]. Behav Pharmacol. 2012;23(8):790-801.