[CAS NO. 123690-79-9] CGP35348
PRODUCTS SPECIFICATIONS [123690-79-9]
DESCRIPTION [123690-79-9]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 225.22 |
| Molecular Formula | C8H20NO4P |
| SMILES | O=P(C(OCC)OCC)(CCCN)O |
Summary
CGP 35348 is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC 50 of 34 μM. CGP 35348 shows affinity for the GABAB receptor only [1] . CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage [2] .
In Vivo
CGP 35348 enhances non-REM sleep and rapid eye movement (REM) sleep and reduces strongly spike-wave discharges [3] .
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
| Animal Model: | Eight male Wistar rats [3] |
| Dosage: | 100, 300, and 900 mg/kg |
| Administration: | Intraperitoneally given |
| Result: | Produced an increase in the duration of REM sleep compared to the saline-injected control group at 100 and 300 mg/kg. |
Appearance
Oil
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
Solvent & Solubility
H 2 O : 83.33 mg/mL ( 369.99 mM ; Need ultrasonic)
Stock Solutions
| Concentration Solvent Mass | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 4.4401 mL | 22.2005 mL | 44.4010 mL |
| 5 mM | 0.8880 mL | 4.4401 mL | 8.8802 mL |
| 10 mM | 0.4440 mL | 2.2201 mL | 4.4401 mL |
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1.
Add each solvent one by one: PBS
Solubility: 25 mg/mL (111.00 mM); Clear solution; Need ultrasonic
References
- [1] H R Olpe,et al. CGP 35348: a centrally active blocker of GABAB receptors. CGP 35348: a centrally active blocker of GABAB receptors
- [2] Q Gillani, et al. CGP 35348, GABA B receptor antagonist, has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage. Biomed Res Int. 2014;2014:295215.
- [3] A Puigcerver, et al. Effects of the GABAB antagonist CGP 35348 on sleep-wake states, behaviour, and spike-wave discharges in old rats. Brain Res Bull. 1996;40(3):157-62.
Synonyms