[CAS NO. 1252637-35-6]  Petesicatib

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PRODUCTS SPECIFICATIONS [1252637-35-6]

Catalog
AS960872
Brand
Arctom Scientific
CAS
1252637-35-6

DESCRIPTION [1252637-35-6]

Overview

MDL-
Molecular Weight603.54
Molecular FormulaC25H23F6N5O4S
SMILESO=C(N1[C@@H](C[C@@H](S(=O)(C2=C(C=C(C3=CN(C)N=C3)C=C2)C(F)(F)F)=O)C1)C(NC4(CC4)C#N)=O)C5(CC5)C(F)(F)F

For research use only. We do not sell to patients.

Summary

Petesicatib is a cathepsin S inhibitor, used in research of immune diseases [1] .


IC50 & Target

Cathepsin S [1]


In Vitro

Petesicatib (Example 238) is a cathepsin S inhibitor, used in research of immune diseases [1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.


Appearance

Solid


Shipping

Room temperature in continental US; may vary elsewhere.


Storage

Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL ( 207.11 mM ; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6569 mL 8.2845 mL 16.5689 mL
5 mM 0.3314 mL 1.6569 mL 3.3138 mL
10 mM 0.1657 mL 0.8284 mL 1.6569 mL
* Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

    Solubility: ≥ 2.08 mg/mL (3.45 mM); Clear solution

  • 2.

    Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.45 mM); Clear solution

  • 3.

    Add each solvent one by one: 10% DMSO >> 90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.45 mM); Clear solution

* All of the co-solvents are available by MCE.