[CAS NO. 1258494-60-8] TH1338

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PRODUCTS SPECIFICATIONS [1258494-60-8]

Catalog

AS961046

Brand

Arctom Scientific

CAS

1258494-60-8

DESCRIPTION [1258494-60-8]

Overview

MDL	MFCD23381068
Molecular Weight	391.42
Molecular Formula	C22H21N3O4
SMILES	O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(CC)C5=CC=CC=C5N=C4C3=C2N)=O

For research use only. We do not sell to patients.

Summary

TH1338 (compound 3b), an orally active camptothecin derivative and a potent chemotherapeutic agent for cancer , demonstrates excellent cytotoxic potency against human tumor cell lines in vitro. TH1338 (compound 3b) possesses significant brain penetration, favorable efflux pump properties, and hematological toxicity profile ^[1] ^[2] .

In Vitro

TH1338 (compound 3b) demonstrates significant brain penetration when dosed orally in mice ^[1] .
TH1338 (compound 3b) exhibits potent anti-tumor activity in H460 (NSCLC) human tumor xenograft model ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay ^[1]

Cell Line:	H460 (NSCLC) human tumor xenograft model.
Concentration:	40 mg/kg.
Incubation Time:	Oral gavage.
Result:	Exhibited superior antitumor activity.

Appearance

Solid

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL ( 25.55 mM ; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5548 mL	12.7740 mL	25.5480 mL
5 mM	0.5110 mL	2.5548 mL	5.1096 mL
10 mM	0.2555 mL	1.2774 mL	2.5548 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 1.82 mg/mL (4.65 mM); Clear solution

* All of the co-solvents are available by MCE.